Tetrahedron p. 1025 - 1038 (1990)
Update date:2022-07-29
Topics:
Jonczyk, Andrzej
Lipiak, Dariusz
Zdrojewski, Tadeusz
It has been found that morpholinonitrile 1a reacts with acetylene (2) in the presence of solid sodium hydroxide and tetrabutylammonium bromide (TBABr) as a catalyst, in DMSO, to give the vinyl derivative 3a. Whereas aminonitriles 1b-i, in the reaction with 2, afford dienamines 7. The different reactivity of 1a as compared to 1b-i is explained in terms of the different basicity of the amino moiety in vinyl derivatives 3. Dienamines 7 were hydrolyzed to 1,4-diarylbutan-1,4-diones 8 in high yields.
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(1983)