
Tetrahedron Letters p. 7017 - 7020 (1989)
Update date:2022-08-02
Topics:
Martin
Cheavens
A stereoselective two step sequence for the construction of fused pyrrolidone ring systems has been developed which features the intramolecular [3 + 2] dipolar cycloaddition of unsaturated azomethine ylides. The ylides are produced upon reaction of aminomethylphosphonates with α,ω-olefinic aldehydes, followed by oxidative removal of the phosphonate ester group using a newly developed method.
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