Synthesis and anti-HIV-1 activity of 2'-'up'-fluoro analogues of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC)

DOI: 10.1021/jm00170a016

Source and publish data:

Journal of Medicinal Chemistry p. 2145 - 2150 (1990)

Update date:2022-08-03

Topics:

Authors:

Watanabe

Harada Harada

Zeidler Zeidler

Matulic-Adamic

Takahashi

Ren Ren

Cheng Cheng

Fox Fox

Chou Chou

Zhu Zhu

Polsky Polsky

Gold Gold

Armstrong

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Article abstract of DOI:10.1021/jm00170a016

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (6, F-AZT) and 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12, F-DDC) were synthesized from the potent antiherpes virus nucleosides 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine

Full text of DOI:10.1021/jm00170a016

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Product name:1-(2-deoxy-2-fluoro-5-O-trityl-β-D-arabinofuranosyl)-5-iodocytosine

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