An efficient phosphorylation method using a new phosphitylating agent, 2-diethylamino-1,3,2-benzodioxaphosphepane

Article abstract of DOI:10.1016/S0040-4039(00)94385-5

A variety of alcohols containing polyols like inositol derivatives were efficiently phosphitylated by the reaction with 2-diethylamino-1,3,2-benzodioxaphosphepane in the presence of tetrazole and the resulting phosphites were oxidized with mCPBA or sulfur to yield the corresponding phosphates or thiophosphates in excellent yields.