Design, synthesis and evaluation of a chiral propranolol selector

Article abstract of DOI:10.1016/0957-4166(96)00337-0

Synthesis of enantiomerically pure (S)-(-)-propranolol, the most active of the widely used beta-blockers adrenergics, was achieved using a new chiral stationary phase (CSP) for the separation of a derivative. This simple methodology shows a significant improvement in the separation of the enantiomers of a propranolol derivative over previous methods.