Total synthesis of (+)-mayolide A. Absolute structure of mayolide A, a sacocembrane diterpenoid from the soft coral Sinularia mayi

Article abstract of DOI:10.1248/cpb.40.1742

The stereoselective total synthesis of (+)-mayolide A (1) was achieved starting from D-mannitol via two crucial steps: stereoselective introduction of a two-carbon unit into the β-position of the butenolide 5 and repeated Claisen rearrangement to produce the side chain. The absolute structure of natural mayolide A from the Okinawan soft coral Sinularia mayi was determined as 2 by the present synthesis.

Full text of DOI:10.1248/cpb.40.1742

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