Copper-catalyzed C-P bond construction via direct coupling of phenylboronic acids with H-phosphonate diesters

Article abstract of DOI:10.1021/ol200465z

A mild and efficient method was developed for the copper-catalyzed additions of H-phosphonate diesters to boronic acids under the copper catalyst system Cu₂O/1,10-phenanthroline. To the best of our knowledge this finding is the first example of a copper-catalyzed synthesis of aryl phosphonates from arylboronic acids and H-phosphonate dialkyl esters.