Synthesis, gastrointestinal prokinetic activity and structure-activity relationships of novel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives

DOI: 10.1248/cpb.40.202

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 202 - 211 (1992)

Update date:2022-08-05

Topics:

Authors:

Sakaguchi

Nishino Nishino

Ogawa Ogawa

Iwanaga Iwanaga

Yasuda Yasuda

Kato Kato

Ito Ito

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.202

Novel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives (II-1-51), derived from the structural modification of metoclopramide (1), were synthesized and examined for their pharmacological activities. Among them, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide (II-34) which exhibited well balanced gastrointestinal prokinetic and antiemetic activities was selected as a new type of gastrointestinal prokinetic agent.

Full text of DOI:10.1248/cpb.40.202

NII-Electronic Library Service

Products guided by the article

Product name:Benzenemethanamine, 4-[2-(4-methyl-1-piperidinyl)ethoxy]-

Cas No:128540-38-5

R&D Labs maybe for 128540-38-5

Shanghai PuYi Chem-Tech Co.,Ltd.

Contact:+86-21-57687505-227

Address:3 Floor, Building 11, No 201 MinYi Road, Songjiang District, Shanghai 201612, China
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Shanghai Yuanye Bio-Technology Co., Ltd.

website:http://www.shyuanye.com

Contact:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Shanghai FWD Chemicals ltd

website:http://www.fwdchem.com

Contact:86-21-54450828

Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Chinapeptides Co,. Ltd

Contact:+86-021-50792271

Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202

Relevant to this article

Heterogeneous catalysis: Ni/C-catalyzed cross-couplings en route to allylated aromatics: Application to a precursor to coenzyme Q₁₀

Doi:10.1055/s-2002-34384
(2002)
Modified borohydride agents; Efficient reduction of azides with (1,4- diazabicyclo[2.2.2]octane) (tetrahydroborato)zinc complex [Zn(BH₄)₂(dabco)] and methyltriphenylphosphonium tetrahydroborate [MePh₃P⁺BH^-₄]

Doi:10.1080/00397919808005968
(1998)
Azaindole anthelmintic agents.

Doi:10.1021/jm00281a019
(1972)
Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives

Doi:10.1016/j.ejmech.2016.07.024
(2016)
Discovery of phthalimide derivatives as novel inhibitors of a soluble epoxide hydrolase

Doi:10.1002/ardp.202000052
(2020)
Doi:10.1039/P19730000316
(1973)

Article Doi