Synthesis, gastrointestinal prokinetic activity and structure-activity relationships of novel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives

DOI: 10.1248/cpb.40.202

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 202 - 211 (1992)

Update date:2022-08-05

Topics:

Authors:

Sakaguchi

Nishino Nishino

Ogawa Ogawa

Iwanaga Iwanaga

Yasuda Yasuda

Kato Kato

Ito Ito

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.202

Novel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives (II-1-51), derived from the structural modification of metoclopramide (1), were synthesized and examined for their pharmacological activities. Among them, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide (II-34) which exhibited well balanced gastrointestinal prokinetic and antiemetic activities was selected as a new type of gastrointestinal prokinetic agent.

Full text of DOI:10.1248/cpb.40.202

NII-Electronic Library Service

Products guided by the article

Product name:Benzenemethanamine, 4-[2-(4-methyl-1-piperidinyl)ethoxy]-

Cas No:128540-38-5

R&D Labs maybe for 128540-38-5

Shenyang Xingzhenghe Chemical Co., Ltd.

Contact:024-23509232

Address:No. 33, Naner Road, Heping Dist.
DU-HOPE INTERNATIONAL GROUP

Contact:+86-25-52346955

Address:199,JIANYE ROAD,NANJING,CHINA
Onlychem (Jinan)Biotech Co.,Ltd

Contact:86-531-83175885

Address:No. 44, Honglou South Road, Jinan,China
Heading（Nanjing）Pharmtechnologies

Contact:86 25 58467899-950 025-58862846-950

Address:Room C413 Fengyu Building, 115 Fucheng Road, Haidian District, Beijing 100142, China
Lishui Nanming Chemical Co., Ltd(expird)

Contact:+86-0578-2134101，2697830

Address:No.19 Tongji Road Shuige Industrial zone

Relevant to this article

Heterogeneous catalysis: Ni/C-catalyzed cross-couplings en route to allylated aromatics: Application to a precursor to coenzyme Q₁₀

Doi:10.1055/s-2002-34384
(2002)
Modified borohydride agents; Efficient reduction of azides with (1,4- diazabicyclo[2.2.2]octane) (tetrahydroborato)zinc complex [Zn(BH₄)₂(dabco)] and methyltriphenylphosphonium tetrahydroborate [MePh₃P⁺BH^-₄]

Doi:10.1080/00397919808005968
(1998)
Azaindole anthelmintic agents.

Doi:10.1021/jm00281a019
(1972)
Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives

Doi:10.1016/j.ejmech.2016.07.024
(2016)
Discovery of phthalimide derivatives as novel inhibitors of a soluble epoxide hydrolase

Doi:10.1002/ardp.202000052
(2020)
Doi:10.1039/P19730000316
(1973)

Article Doi