Synthesis, gastrointestinal prokinetic activity and structure-activity relationships of novel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives

DOI: 10.1248/cpb.40.202

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 202 - 211 (1992)

Update date:2022-08-05

Topics:

Authors:

Sakaguchi

Nishino Nishino

Ogawa Ogawa

Iwanaga Iwanaga

Yasuda Yasuda

Kato Kato

Ito Ito

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Article abstract of DOI:10.1248/cpb.40.202

Novel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives (II-1-51), derived from the structural modification of metoclopramide (1), were synthesized and examined for their pharmacological activities. Among them, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide (II-34) which exhibited well balanced gastrointestinal prokinetic and antiemetic activities was selected as a new type of gastrointestinal prokinetic agent.

Full text of DOI:10.1248/cpb.40.202

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