Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

DOI: 10.1021/jm00082a020

Source and publish data:

Journal of Medicinal Chemistry p. 780 - 793 (1992)

Update date:2022-08-04

Topics:

Authors:

Kimball Kimball

Floyd Floyd

Das Das

Hunt Hunt

Krapcho Krapcho

Rovnyak Rovnyak

Duff Duff

Lee Lee

Moquin Moquin

Turk Turk

Hedberg Hedberg

Moreland

Brittain

McMullen

Normandin

Cucinotta

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Article abstract of DOI:10.1021/jm00082a020

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc

Full text of DOI:10.1021/jm00082a020

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