Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

DOI: 10.1021/jm00082a020

Source and publish data:

Journal of Medicinal Chemistry p. 780 - 793 (1992)

Update date:2022-08-04

Topics:

Authors:

Kimball Kimball

Floyd Floyd

Das Das

Hunt Hunt

Krapcho Krapcho

Rovnyak Rovnyak

Duff Duff

Lee Lee

Moquin Moquin

Turk Turk

Hedberg Hedberg

Moreland

Brittain

McMullen

Normandin

Cucinotta

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00082a020

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc

Full text of DOI:10.1021/jm00082a020

Products guided by the article

Product name:cis-1,3,4,5-tetrahydro-3-methyl-6-(trifluoromethyl)-1-<2-(dimethylamino)-1-methylethyl>-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Cas No:128573-82-0

R&D Labs maybe for 128573-82-0

Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Shanghai Yuanye Bio-Technology Co., Ltd.

website:http://www.shyuanye.com

Contact:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Naturalin Bio-Resource Co., Ltd

website:http://www.naturalin.com

Contact:+86-0731-84430651

Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China

Relevant to this article

Hexahydroquinolinones with Calcium-modulatory effects - Synthesis and pharmalogical efficacy

Doi:10.1002/ardp.19903230506
(1990)
Studies on the stereoselective methylation of α-sulfinyl carbanions generated from three isomeric pyridylmethyl π-tolyl sulfoxides and benzyl 2-pyridyl sulfoxide

Doi:10.1246/bcsj.63.461
(1990)
Reformatsky Reaction on α-Oxo Ketene Dithioacetals: Synthesis of Substituted and Fused Ethyl 2-Hydroxy-6-(methylthio)benzoates, 6-(Methylthio)pyran-2-ones, and 6-(Methylthio)-2(1H)-pyridone Derivatives

Doi:10.1021/jo00308a015
(1990)
Doi:10.1021/jo01051a535
(1962)
A novel method for the preparation of peptidyl α-keto esters

Doi:10.1016/S0040-4039(00)88812-7
(1990)
Electrochemical approach for synthesis of 3-substituted indole derivatives

Doi:10.1016/j.tetlet.2017.09.003
(2017)

Article Doi