Journal of Medicinal Chemistry p. 780 - 793 (1992)
Update date:2022-08-04
Topics:
Kimball
Floyd
Das
Hunt
Krapcho
Rovnyak
Duff
Lee
Moquin
Turk
Hedberg
Moreland
Brittain
McMullen
Normandin
Cucinotta
We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc
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