Studies on the stereoselective methylation of α-sulfinyl carbanions generated from three isomeric pyridylmethyl π-tolyl sulfoxides and benzyl 2-pyridyl sulfoxide

DOI: 10.1246/bcsj.63.461

Source and publish data:

Bulletin of the Chemical Society of Japan p. 461 - 465 (1990)

Update date:2022-08-04

Topics:

Authors:

Furukawa

Hosono Hosono

Fujihara

Ogawa Ogawa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/bcsj.63.461

A high stereoselectivity in the methylation of 2-pyridylmethyl p-totyl sulfoxide (2a) with lithium diisopropylamide and iodomethane was observed at low temperature. The chelation of Li⁺ by both the nitrogen atom in the pyridine ring and the sulfinyl oxygen atom in 2a promotes the stereoselectivity as compared with isomeric sulfoxides.

Full text of DOI:10.1246/bcsj.63.461

Products guided by the article

Product name:Toluene-4-sulfonic acid (R)-1-pyridin-2-yl-ethyl ester

Cas No:128916-40-5

R&D Labs maybe for 128916-40-5

Chengdu Shengnuo Biological Technology Co., Ltd.

Contact:86-028-85275045

Address:Sichuan Province Chengdu hi tech Zone Tianfu Avenue North of 1480
Beijing Century Richap Chemistry Co.,Ltd

Contact:+86- 010-64455497

Address:Guannan County, Lianyungang City, Jiangsu Province, China
Improve Medical Technology(Nanxiong) Co., Ltd

Contact:86-751-3836997

Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
Molobelamltrading

Contact:27-792-602929

Address:SIDNEY MUFAMADI STREET 009949 X44 0700 POLOKWANE,LIMPOPO
TC CHEMICALS CO.,LTD

Contact:0550-7041128 0550-7090578

Address:Wangdian Street,Xinjie Town

Relevant to this article

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors

Doi:10.1016/j.ejmech.2015.11.010
(2016)
Enantioselective Vicinal Diacetoxylation of Alkenes under Chiral Iodine(III) Catalysis

Doi:10.1055/s-0035-1561313
(2016)
Synthesis and calcium antagonistic activity of (+)-(R)- and (-)-(S)-3-acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5-trimethoxyphenet hyl)amino]butoxy]phenyl]benzothiazoline hydrochloride

Doi:10.1248/cpb.38.936
(1990)
Doi:10.1039/jr9630005706
(1963)
(8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino<2,1-g><1,6>naphthyridine, a Potent and Highly Selective α₂-Adrenoceptor Antagonist

Doi:10.1021/jm00129a002
(1989)
Influence of the β-Substitution on the Photochemistry of α,2-Diacetoxystyrenes. Irradiatin of Phenyl, Vinyl, and Benzyl Derivatives

Doi:10.1007/BF00808927
(1990)

Article Doi