Increasing 5-lipoxygenase inhibitory activities by oxidative conversion of o-methoxyphenols to catechols using a Cu2+ - ascorbic acid - O2 system

DOI: 10.1248/cpb.38.842

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 842 - 844 (1990)

Update date:2022-08-04

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Authors:

Aihara Aihara

Higuchi Higuchi

Hirobe Hirobe

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Article abstract of DOI:10.1248/cpb.38.842

Several complicated o-methoxyphenols were oxidized with high selectivity to catechols by a Cu²⁺ - ascorbic acid - O₂ system. In this way, the RBL-1 5-lipoxygenase inhibitory activities of o-methoxyphenols were greatly increased. [6]-Norgingerol (4), a novel compound derived from [6]-gingerol (3), shows promise as a lead compound for new drugs because of its high inhibitory potency (IC₅₀ = 5.0 x 10^-8 M).

Full text of DOI:10.1248/cpb.38.842

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