Synthesis and crystal and molecular structure of new N-substituted γ-hydroxybutyramides

Article abstract of DOI:10.1007/BF01160965

The N-(2-phenylethyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (II) and the N-(p-methoxybenzyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (III) have been synthesized and the crystal structure of III has been solved.Compound III, C16H23O5N, crystallizes in the monoclinic space group P2₁/c with a = 12.572(2), b = 11.149(2), c = 12.317(2) Angstroem and β = 106.53(1) deg.The structure was solved by direct methods, and refined by full-matrix least squares to give R = 0.040 (R_w = 0.047) for 2004 intensities.The dioxolane ringhas a deformed half-chair conformation.