
Tetrahedron Letters p. 3845 - 3848 (1989)
Update date:2022-08-06
Topics:
Bradbury, Robert H.
Revill, John M.
Rivett, Janet E.
Waterson, David
An efficient synthetic route is described to the γ-lactone 11 corresponding to the dipeptide isostere (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanoic acid, in which stereochemical control is achieved by participation of chiral acyloxazolidinone 6 in a stereoselective bromolactonisation reaction.
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