Potent Inhibition of Pepsin and Penicillopepsin by Phosphorus-Containing Peptide Analogues

DOI: 10.1021/jo00313a012

Source and publish data:

Journal of Organic Chemistry p. 6268 - 6274 (1990)

Update date:2022-07-30

Topics:

Authors:

Bartlett, Paul A.

Hanson, John E.

Giannousis, Peter P.

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Article abstract of DOI:10.1021/jo00313a012

Phosphinic and phosphonic acid peptide derivatives have been evaluated as inhibitors of the aspartic proteases pepsin and penicillopepsin.The most potent of those studied is isovaleryl-Val-Val-Leu^P-(O)Phe-Ala-Ala-OMe (4) (Leu^P repres

Full text of DOI:10.1021/jo00313a012

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