European Journal of Medicinal Chemistry p. 735 - 742 (1992)
Update date:2022-08-05
Topics: Anti-Inflammatory Effects Antioxidant Effects Immunomodulation Cholesterol Lowering Endothelial Function Improvement Plaque Stability
Regan
Bruno
Gustafson
Amin
Neuenschwander
Perrone
We report on a series of potent inhibitors of HMG-CoA reductase (HMGR) that were designed to examine the biological consequences that result from molecular changes in RG 12561. The introduction of functional groups on the cyclohexene nucleus of RG 12561 a
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