Journal of Medicinal Chemistry p. 3646 - 3657 (1993)
Update date:2022-08-05
Topics: HMG-CoA Reductase
Chan
Bailey
Hartley
Hayman
Hutson
Inglis
Jones
Keeling
Kirk
Lamont
Lester
Pritchard
Ross
Scicinski
Spooner
Smith
Steeples
Watson
3,5-Dihydroxy-7-(N-imidazolyl)heptanoates 4 and the corresponding heptenoates 5 were synthesized as novel classes of potent HMG-CoA reductase (HMGR) inhibitors in which members of the latter series possess enzyme inhibitory activity greater than that of l
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