PHYLLANTHOSIDE-PHYLLANTHOSTATIN SYNTHETIC STUDIES. 6. AN AUGMENTED SPIROKETALIZATION TACTIC FOR THE TOTAL SYNTHESIS OF PHYLLANTHOCIN

Article abstract of DOI:10.1016/S0040-4039(00)70688-5

An enhanced spiroketalization maneuver permitting equilibration at both the C(8) and C(11) centers of spiroketals 17a,b leads to a more concise and efficient synthesis of phyllanthocin (i.e., 21 steps, 5.6percent overall yield).