Synthesis and antitumor activity of various 6-demethylmitomycins and 6- demethyl-6-halomitomycins

DOI: 10.1021/jm00016a005

Source and publish data:

Journal of Medicinal Chemistry p. 3025 - 3033 (1995)

Update date:2022-09-26

Topics:

Authors:

Arai Arai

Ashizawa

Gomi Gomi

Kono Kono

Saito Saito

Kasai Kasai

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Article abstract of DOI:10.1021/jm00016a005

A series of 6-demethylmitomycins and 6-demethyl-6-halomitomycins having various mitomycin skeletons were synthesized, taking into account the electronic effect toward the quinone moiety and the partition coefficients. Treatment of enones 15 and 16 with se

Full text of DOI:10.1021/jm00016a005

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