Journal of Medicinal Chemistry p. 1233 - 1245 (1992)
Update date:2022-09-26
Topics:
Thomas, Edward W.
Cudahy, Michele M.
Spilman, Charles H.
Dinh, Dac M.
Watkins, Tommie L.
Vidmar, Thomas J.
A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine.Two of these compounds, N,N-bis<2-(cyclododecylamino)ethyl>-N'-benzyl-1,2-ethanediamine trihydrochloride (36*3HCl) and N,N-bis<2-(cyclododecylmethylamino)ethyl>-N',N'-dimethyl-1,2-ethanediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.
View MoreNanjing Ruizhi Industry & Technologh Co.，Ltd.
Contact:+86-25-86808110
Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Contact:86-510-82853889
Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
website:http://www.chinabarton.com
Contact:+86-573-82719618
Address:No. 162 Fumin Road, Honghe Town,
Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)
website:http://www.bjgreenchem.com/
Contact:+86-427-6515887
Address:301,302, 3rd Floor, Building C-7, Dongsheng Science Park, Northern Territory, Zhongguancun, No. 66, Xixiaokou Road, Haidian District, Beijing
Contact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
Doi:10.1134/S1070428011020187
(2011)Doi:10.1016/0022-328X(90)80007-M
(1990)Doi:10.1021/ja00177a044
(1990)Doi:10.1016/j.bmcl.2011.01.116
(2011)Doi:10.1039/c0ob00937g
(2011)Doi:10.1016/j.bmcl.2011.01.058
(2011)
