Cholesterol Lowering Bile Acid Binding Agents: Novel Lipophilic Polyamines

Article abstract of DOI:10.1021/jm00085a011

A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine.Two of these compounds, N,N-bis<2-(cyclododecylamino)ethyl>-N'-benzyl-1,2-ethanediamine trihydrochloride (36*3HCl) and N,N-bis<2-(cyclododecylmethylamino)ethyl>-N',N'-dimethyl-1,2-ethanediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.