Journal of Medicinal Chemistry p. 1233 - 1245 (1992)
Update date:2022-09-26
Topics:
Thomas, Edward W.
Cudahy, Michele M.
Spilman, Charles H.
Dinh, Dac M.
Watkins, Tommie L.
Vidmar, Thomas J.
A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine.Two of these compounds, N,N-bis<2-(cyclododecylamino)ethyl>-N'-benzyl-1,2-ethanediamine trihydrochloride (36*3HCl) and N,N-bis<2-(cyclododecylmethylamino)ethyl>-N',N'-dimethyl-1,2-ethanediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.
View MoreHangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
website:http://www.truewingroup.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Tai zhou world Pharm & Chem Co., Ltd
Contact:+86-576-85301198
Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
Melone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)
Contact:22-58516360
Address:tianjin
Doi:10.1134/S1070428011020187
(2011)Doi:10.1016/0022-328X(90)80007-M
(1990)Doi:10.1021/ja00177a044
(1990)Doi:10.1016/j.bmcl.2011.01.116
(2011)Doi:10.1039/c0ob00937g
(2011)Doi:10.1016/j.bmcl.2011.01.058
(2011)
