Journal of Medicinal Chemistry p. 1233 - 1245 (1992)
Update date:2022-09-26
Topics:
Thomas, Edward W.
Cudahy, Michele M.
Spilman, Charles H.
Dinh, Dac M.
Watkins, Tommie L.
Vidmar, Thomas J.
A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine.Two of these compounds, N,N-bis<2-(cyclododecylamino)ethyl>-N'-benzyl-1,2-ethanediamine trihydrochloride (36*3HCl) and N,N-bis<2-(cyclododecylmethylamino)ethyl>-N',N'-dimethyl-1,2-ethanediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.
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