Journal of Medicinal Chemistry p. 1233 - 1245 (1992)
Update date:2022-09-26
Topics:
Thomas, Edward W.
Cudahy, Michele M.
Spilman, Charles H.
Dinh, Dac M.
Watkins, Tommie L.
Vidmar, Thomas J.
A series of novel lipophilic polyamines was synthesized by the sodium cyanoborohydride-mediated reductive amination of various ketones and aldehydes with the polyamine tris(2-aminoethyl)amine.Two of these compounds, N,N-bis<2-(cyclododecylamino)ethyl>-N'-benzyl-1,2-ethanediamine trihydrochloride (36*3HCl) and N,N-bis<2-(cyclododecylmethylamino)ethyl>-N',N'-dimethyl-1,2-ethanediamine (23), are 29 and 24 times more potent than colestipol hydrochloride, respectively, for lowering animal serum cholesterol levels.
View MoreBeijing Harmony Chemical Co., Ltd.
Contact:86-010-84956928
Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008
Shenzhen Feiming Science and Technology Co,. Ltd
Contact:+86-755-85232577
Address:#B2309, Fenglin International Center ,Jixiang Road, Longcheng street, LongGang District, Shenzhen city, Guangdong province, China.
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
Antaeus Bio-technology Co., LTD(expird)
Contact:021-31252569
Address:shanghai pudong
Doi:10.1134/S1070428011020187
(2011)Doi:10.1016/0022-328X(90)80007-M
(1990)Doi:10.1021/ja00177a044
(1990)Doi:10.1016/j.bmcl.2011.01.116
(2011)Doi:10.1039/c0ob00937g
(2011)Doi:10.1016/j.bmcl.2011.01.058
(2011)
