Synthesis of 1,2,3-trisubstituted and 1,2,2,3-tetrasubstituted aziridines from α-chloroketimines

Article abstract of DOI:10.1016/S0040-4020(01)88388-5

Secondary α-chloroketimines react with lithium aluminium hydride in ether to afford mixtures of cis-and trans-1,2,3-trisubstituted aziridines. The reaction products are formed by nucleophilic addition of hydride across the imino bond and subsequent intram