CONJUGATE ADDITION OF CUPRATE REAGENTS TO CHROMONES: A ROUTE TO 2-SUBSTITUTED CHROMAN-4-ONES

Article abstract of DOI:10.1016/S0040-4020(01)88394-0

Chromones (4-oxo-4H-1-benzopyrans) activated by electron-withdrawing groups attached to C-3 undergo efficient 1,4-addition of cuprate reagents, producing 2,3-disubstituted chroman-4-ones.The addition products from methyl chromone-3-carboxylates can be converted into 2-substituted chroman-4-ones by treatment with sodium chloride in wet dimethylsulphoxide.