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203–204ꢁC; yield 60–80%, Stecher et al., 1973).
2-Bromo-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-
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1
1490 (C=N, C=C and aromatics); 594 (C–Br). H NMR (d
ppm): 2.33 (s, 3H, CH3); 2.43 (s, 3H, CH3); 7.43–7.52 (m,
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band with multiple splits (OH-acid); 1697(CO); 1617,
1598, 1568, 1533, 1502 (C=N, C=C and aromatics); 1004,
1
684 (C–Br). H NMR (d ppm): 7.33–7.37 (m, 2H, phenyl-
C-4-H and olefinic-H); 7.46–7.56 (t, J = 7.65 Hz, 2H,
phenyl-C-3,5-H); 7.55 (d, J = 8.4 Hz, 2H, 4-bromophenyl-
C-2,6-H); 7.72 (d, J = 8.4 Hz, 2H, 4-bromophenyl-C-3,5-
H); 7.80 (d, J = 7.65 Hz, 2H, phenyl-C-2,6-H); 8.77(s, 1H,
pyrazole-C-5-H). Anal. Calcd. for C18H12Br2N2O2
(448.11): C, 48.25; H, 2.70; N, 6.25. Found: C, 47.91; H,
2.80; N, 5.98.
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Acknowledgments The authors are grateful to Dr. L. Meijer, Le
Centre Nationale des Recherches Scientifiques, Roscoff Cedex,
France, for screening representative compounds against CDKs. They
also thank the staff of the Developmental Therapeutics Program,
Division of Cancer Treatment, National Cancer Institute, Bethesda,
MD, USA, for the anti-cancer test report. Thanks are also extended to
the staff of the Department of Pharmaceutical Microbiology, Faculty
of Pharmacy, University of Alexandria, AR Egypt, for the anti-
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