New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

DOI: 10.1016/0040-4039(92)89019-9

Source and publish data:

Tetrahedron Letters p. 5737 - 5740 (1992)

Update date:2022-09-26

Topics: Synthon Analog Enantiomeric purity β-Lactam Experimental terms Efficient routes

Authors:

Ojima, Iwao

Park, Young Hoon

Sun, Chung Ming

Brigaud, Thierry

Zhao, Mangzhu

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Article abstract of DOI:10.1016/0040-4039(92)89019-9

Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.

Full text of DOI:10.1016/0040-4039(92)89019-9

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