Tetrahedron Letters p. 5737 - 5740 (1992)
Update date:2022-09-26
Topics: Synthon Analog Enantiomeric purity β-Lactam Experimental terms Efficient routes
Ojima, Iwao
Park, Young Hoon
Sun, Chung Ming
Brigaud, Thierry
Zhao, Mangzhu
Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.
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