Nonsteroidal cardiotonics. 3. New 4,5-dihydro-6-(1H-indol-5-yl)pyridazine-3(2H)-ones and related compounds with positive inotropic activities

DOI: 10.1021/jm00172a031

Source and publish data:

Journal of Medicinal Chemistry p. 2870 - 2875 (1990)

Update date:2022-08-05

Topics: Pharmacophore Lead Optimization Indole In vitro assay In vivo assay SAR (Structure-Activity Relationship) Synthetic derivatives Positive inotropic activity Pyridazine Cardiotonic agent EC50 (Half-Maximal Effective Concentration)

Authors:

Mertens Mertens

Friebe Friebe

Muller-Beckmann

Kampe Kampe

Kling Kling

Von der Saal

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Article abstract of DOI:10.1021/jm00172a031

A sereis of substituted indolyldihydropyridazinones and related compounds 1-18 were synthesized and evaluated for positive inotropic activity. In rats, most of these indole derivatives produced a dose-related increase in myocardial contractility with litt

Full text of DOI:10.1021/jm00172a031

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