Nonsteroidal cardiotonics. 3. New 4,5-dihydro-6-(1H-indol-5-yl)pyridazine-3(2H)-ones and related compounds with positive inotropic activities

DOI: 10.1021/jm00172a031

Source and publish data:

Journal of Medicinal Chemistry p. 2870 - 2875 (1990)

Update date:2022-08-05

Topics: Pharmacophore Lead Optimization Indole In vitro assay In vivo assay SAR (Structure-Activity Relationship) Synthetic derivatives Positive inotropic activity Pyridazine Cardiotonic agent EC50 (Half-Maximal Effective Concentration)

Authors:

Mertens Mertens

Friebe Friebe

Muller-Beckmann

Kampe Kampe

Kling Kling

Von der Saal

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00172a031

A sereis of substituted indolyldihydropyridazinones and related compounds 1-18 were synthesized and evaluated for positive inotropic activity. In rats, most of these indole derivatives produced a dose-related increase in myocardial contractility with litt

Full text of DOI:10.1021/jm00172a031

Products guided by the article

Product name:4,4-Dimethyl-5-(4-{N'-[1-pyridin-4-yl-eth-(E)-ylidene]-hydrazino}-phenyl)-2,4-dihydro-pyrazol-3-one

Cas No:129593-98-2

R&D Labs maybe for 129593-98-2

Anqing World Chemical Co., Ltd.

Contact:+86-556-5800026

Address:Daguan Economic Development Zone of circular economy industrial park Anqing City Anhui province
Changsha Yonta Industry Co., Ltd.

Contact:+ 86-731-8535 2228

Address:Rm.1717, North Bldg., No.368, East 2nd Ring Road(2nd Section)
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park
Meryer (Shanghai) Chemical Technology Co., Ltd.

website:http://www.meryer.com/cn/index/

Contact:+86-755-86170518

Address:Minhang,Shanghai, China
Suzhou BEC Fine Chemicals Co., Ltd.

website:http://www.bek.com.cn

Contact:0512-68095917　 18913193865

Address:6, Jin Shan Road, Suzhou New District, 215011 China Suzhou Nations Pharmaceutical Innovation Center Inside

Relevant to this article

Iridium-catalysed direct C-C coupling of methanol and allenes

Doi:10.1038/nchem.1001
(2011)
A structure-activity study of Ni-catalyzed alkyl-alkyl kumada coupling. Improved catalysts for coupling of secondary alkyl halides

Doi:10.1021/ja200270k
(2011)
A second-generation photocage for Zn²⁺ inspired by TPEN: Characterization and insight into the uncaging quantum yields of ZinCleav chelators

Doi:10.1002/chem.201001982
(2011)
Synthesis and reactivity of tin amide complexes

Doi:10.1016/j.ica.2010.12.009
(2011)
Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

Doi:10.1021/np1006718
(2011)
O-Alkylation at the anomeric centre for the stereoselective synthesis of Kdo-α-glycosides

Doi:10.1016/0008-6215(90)84198-4
(1990)

Article Doi