Sugar modified oligonucleotides: II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

Article abstract of DOI:10.1016/S0040-4039(00)94436-8

α-anomeric uridylates, α-rU₆ and α-rU₁₂, have been synthesized for the first time. These non natural α-oligoribonucleotides strongly resist to enzymatic degradation and bind to complementary RNA strands.