Preparation of γ oxo-α-amino acids from silyl enol ethers and glycine cation equivalents; a facile synthesis of (±)-5-hydroxy.4.Oxonorvaline (HON)

Article abstract of DOI:10.1016/S0040-4020(01)88390-3

The synthesis of a series of N-methoxycarbonyl γ-oxo-α-amino acid methyl esters through Lewis acid-induced coupling of the corresponding chloroglycine derivative with different silyl enol ethers is described. The products can be easily converted into the