An additional coordination group leads to extremely efficient chiral iridium catalysts for asymmetric hydrogenation of ketones

Article abstract of DOI:10.1002/anie.201102710

What a turnover! An efficient chiral iridium catalyst that bears a tridentate spiro aminophosphine ligand catalyzes the asymmetric hydrogenation of ketones with excellent enantioselectivities (up to 99.9 % ee) and extremely high turnover numbers (TONs; as high as 4 550 000). Copyright