Chemical Synthesis of Oligoribonucleotides Containing 2-Aminopurine: Substrates for the Investigation of Ribozyme Function

DOI: 10.1021/jo00308a003

Source and publish data:

Journal of Organic Chemistry p. 5547 - 5549 (1990)

Update date:2022-08-03

Topics: Oxidation Alkynes Selective oxidation Cleavage Terminal alkynes

Authors:

Doudna, Jennifer A.

Szostak, Jack W.

Rich, Alexander

Usman, Nassim

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Article abstract of DOI:10.1021/jo00308a003

The chemical synthesis of a fully protected ribonucleoside phosphoramidite, containing 2-aminopurine as the base component, and its incorporation into short oligoribonucleotides as substrate for an engineered riboenzyme from Tetrahymena is described.

Full text of DOI:10.1021/jo00308a003

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