(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors

DOI: 10.1021/jm00172a034

Source and publish data:

Journal of Medicinal Chemistry p. 2892 - 2899 (1990)

Update date:2022-08-05

Topics:

Authors:

Ellingboe

Alessi Alessi

Millen Millen

Sredy Sredy

King King

Prusiewicz

Guzzo Guzzo

VanEngen

Bagli Bagli

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Article abstract of DOI:10.1021/jm00172a034

Pyrimidineacetic acids and (pyrimidinyloxy)acetic acids were synthesized by alkylation, with methyl bromoacetate or tert-butyl bromoacetate as alkylating agents. Alkylation reaction at the nitrogen or oxygen atom for different substrates was found to be s

Full text of DOI:10.1021/jm00172a034

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