Heterocycles p. 2561 - 2573 (1999)
Update date:2022-07-29
Topics:
Goeker, Hakan
Ayhan-Kilcigil, Guelguen
Tuncbilek, Meral
Kus, Canan
Ertan, Rahmiye
Kendi, Engin
Oezbey, Sueheyla
Fort, Merce
Garcia, Celia
Farre, Antonio J.
A number of benzimidazoles, having several substituents on the azole and benzene nuclei and C-2 (methylamino, ethylenediamine, morpholine, piperazine and piperidine) were prepared. Regioselective synthesis was designed for the N1-alkyl substituted benzimidazoles (14-15). X-Ray structure analysis of (14) was also revealed. Compounds were evaluated for their in vitro H1- antihistaminic activity in the isolated guinea-pig ileum method. The compound (11) exhibits best activity.
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