A Convenient Enantioselective Synthesis of trans-2-Aryloxycyclohexan-1-ols Using Pig Liver Acetone Powder (PLAP) as Biocatalyst

DOI: 10.1016/0957-4166(95)00029-O

Source and publish data:

Tetrahedron Asymmetry p. 439 - 454 (1995)

Update date:2022-08-03

Topics:

Authors:

Basavaiah, Deevi

Krishna, Peddinti Rama

Bharathi, Tirumala K.

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Article abstract of DOI:10.1016/0957-4166(95)00029-O

Pig liver acetone powder (PLAP) has been used as a biocatalyst for enantioselective hydrolysis of racemic trans-1-acetoxy-2-aryloxycyclohexanes to produce the resulting (R,R)-2-aryloxycyclohexan-1-ols upto >99percent enantiomeric purities. (R,R)-Selectivity in this hydrolysis of racemic trans-2-aryloxycyclohexyl acetates was explained on the basis of Jones' three dimensional active site-model.

Full text of DOI:10.1016/0957-4166(95)00029-O

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