Anthracyclinones. 5. Glucosaccharino-1,4-lactone as a Chiral Template for the Synthesis of New Anthracyclinones

Article abstract of DOI:10.1021/jo00001a073

Alkylation of dimethoxybenzene 16 with the chiral aldehyde derivative 14 prepared in six steps from α-D-glucosaccharino-1,4-lactone 3 afforded the adduct 17.After suitable transformation of 17, A ring closure was stereoselectively performed using SnCl4 at