Rationally Designed "Dipeptoid" Analogues of CCK. α-Methyltryptophan Derivatives as Highly Selective and Orally Active Gastrin and CCK-B Antagonists with Potent Anxiolytic Properties

DOI: 10.1021/jm00105a062

Source and publish data:

Journal of Medicinal Chemistry p. 404 - 414 (1991)

Update date:2022-08-03

Topics:

Authors:

Horwell, David C.

Hughes, John

Hunter, John C.

Pritchard, Martyn C.

Richardson, Reginald S.

at al. at al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a062

This paper describes the synthesis and structure-activity relationships (SAR) leading to the first rational design of "dipeptoid" analogues of the neuropeptide cholecystokinin (CCK).Compounds *,S^*)>-4-<<2-<<3-(1H-indol-3-yl)-2-m

Full text of DOI:10.1021/jm00105a062

Products guided by the article

Product name:toluene-4-sulfonic acid (R)-2-benzyloxycarbonylamino-2-phenyl-ethyl ester

Cas No:130406-37-0

R&D Labs maybe for 130406-37-0

Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Beijing Mesochem Technology Co.,LTD

website:http://www.mesochem.com

Contact:0086-10-57862036

Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
Cangzhou Senary Chemical Science-tech Co., Ltd

Contact:+86-317-3563899, 3563699

Address:168 Jinde Road, Cangzhou, Hebei, China
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Shuanghe Bio-Technology Limited(expird)

Contact:+86-571-61710758,18968016640

Address:Jinqiao north road 916# Fuyang

Relevant to this article

Doi:10.1016/S0040-4039(01)82824-0
(1966)
A new selenium catalyzed synthesis of S-Alkyl carbonothioates from alcohols, carbon monoxide, sulfur and alkyl halides

Doi:10.1016/S0040-4039(00)97730-X
(1990)
Rhodium-Catalyzed Regioselective Synthesis of Isocoumarins through Benzothiadiazine-Fused Frameworks

Doi:10.1021/acs.orglett.6b01408
(2016)
Synthesis and antimicrobial properties of substituted 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins and cephalosporins

Doi:10.1016/0223-5234(90)90205-H
(1990)
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

Doi:10.1016/j.ejmech.2007.06.017
(2008)
Two-fragment α-adrenolytics 1. Addition of β-aroxyethylamines and N-arylpiperazines to dialkyl vinylphosphonates

Doi:10.1007/bf02494649
(1999)

Article Doi