Rationally Designed "Dipeptoid" Analogues of CCK. α-Methyltryptophan Derivatives as Highly Selective and Orally Active Gastrin and CCK-B Antagonists with Potent Anxiolytic Properties

DOI: 10.1021/jm00105a062

Source and publish data:

Journal of Medicinal Chemistry p. 404 - 414 (1991)

Update date:2022-08-03

Topics:

Authors:

Horwell, David C.

Hughes, John

Hunter, John C.

Pritchard, Martyn C.

Richardson, Reginald S.

at al. at al.

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Article abstract of DOI:10.1021/jm00105a062

This paper describes the synthesis and structure-activity relationships (SAR) leading to the first rational design of "dipeptoid" analogues of the neuropeptide cholecystokinin (CCK).Compounds *,S^*)>-4-<<2-<<3-(1H-indol-3-yl)-2-m

Full text of DOI:10.1021/jm00105a062

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