Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri

DOI: 10.1021/jm00105a006

Source and publish data:

Journal of Medicinal Chemistry p. 29 - 37 (1991)

Update date:2022-08-02

Topics:

Authors:

Remuzon Remuzon

Bouzard Bouzard

Di Cesare

Essiz Essiz

Jacquet Jacquet

Kiechel Kiechel

Ledoussal

Kessler Kessler

Fung-Tomc

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Article abstract of DOI:10.1021/jm00105a006

A series of novel N-1-(mono-, -(di- and -(trifluoro-tert-butyl) quinolones and -naphthyridines has been prepared. Structure-activity relationship (SAR) studies indicated that the in vitro antibacterial potency was the following order: 1-(1,1-dimethyl-2-fl

Full text of DOI:10.1021/jm00105a006

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