Asymmetric Isopropylation of Steroidal 24-Aldehydes for the Synthesis of 24(R)-Hydroxycholesterol

DOI: 10.1016/0957-4166(95)00073-X

Source and publish data:

Tetrahedron Asymmetry p. 767 - 778 (1995)

Update date:2022-08-02

Topics:

Authors:

Okamoto, Makoto

Tabe, Masayasu

Fujii, Takao

Tanaka, Toshio

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Article abstract of DOI:10.1016/0957-4166(95)00073-X

The chiral β-amino alcohols-catalyzed addition of diisopropylzinc to steroidal 24-aldehydes successfully provided 24(R)-hydroxycholesterols in good yields with high diastereoselectivities, which are synthetic intermediates of 1α-24(R)-dihydroxyvitamin D3

Full text of DOI:10.1016/0957-4166(95)00073-X

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