SYNTHESES OF 3'-SUBSTITUTED-2-(CARBOXYCYCLOPROPYL)GLYCINES VIA INTRAMOLECULAR CYCLOPROPANATION. THE FOLDED FORM OF L-GLUTAMATE ACTIVATES THE NON-NMDA RECEPTOR SUBTYPE

Article abstract of DOI:10.1016/S0040-4039(00)94496-4

Four stereoisomers of 3'-methoxymethyl-L-2-(carboxycyclopropyl)glycines, conformationally constrained analogues of L-glutamate, were synthesized in a stereoselective manner from D-serinal derivative.Selective activation of either the NMDA or Non-NMDA receptor by these isomers was observed.