SYNTHESES OF 3'-SUBSTITUTED-2-(CARBOXYCYCLOPROPYL)GLYCINES VIA INTRAMOLECULAR CYCLOPROPANATION. THE FOLDED FORM OF L-GLUTAMATE ACTIVATES THE NON-NMDA RECEPTOR SUBTYPE

DOI: 10.1016/S0040-4039(00)94496-4

Source and publish data:

Tetrahedron Letters p. 4049 - 4052 (1990)

Update date:2022-09-26

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Authors:

Shimamoto, Keiko

Ohfune, Yasufumi

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Article abstract of DOI:10.1016/S0040-4039(00)94496-4

Four stereoisomers of 3'-methoxymethyl-L-2-(carboxycyclopropyl)glycines, conformationally constrained analogues of L-glutamate, were synthesized in a stereoselective manner from D-serinal derivative.Selective activation of either the NMDA or Non-NMDA receptor by these isomers was observed.

Full text of DOI:10.1016/S0040-4039(00)94496-4

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