A Cardioselective, Hydrophilic N,N,N-Trimethylethanaminium α-Tocopherol Analogue That Reduces Myocardial Infarct Size

DOI: 10.1021/jm00105a040

Source and publish data:

Journal of Medicinal Chemistry p. 257 - 260 (1991)

Update date:2022-08-05

Topics:

Authors:

Grisar, J. Martin

Petty, Margaret A.

Bolkenius, Frank N.

Dow, James

Wagner, Joseph

et al. et al.

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Article abstract of DOI:10.1021/jm00105a040

The α-tocopherol analogue 3,4-dihydro-6-hydroxy-N,N,N,2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate (1a, MDL 73404) and its O-acetate 1b (MDL 74270) were synthesized.Compound 1a was found to be hydrophilic (log P = -0.60) and

Full text of DOI:10.1021/jm00105a040

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