Magnesium Ion Mediated Stereospecific Formation of N-Substituted Ethanolamines During Reductive Amination

Article abstract of DOI:10.1016/S0957-4166(00)82370-8

Reductive amination of (R)-O-protected-α-hydroxyketone 1 with primary amines by NaBH4 in the presence of Mg(ClO4)2 led to the exclusive formation of erythro (1R,2S)-O-protected-N-substituted ethanolamines 2 (R = methyl, ethyl, i-propyl, benzyl, phenylethyl).