Synthesis of nine-membered azlactones by palladium-catalyzed ring-expansion of γ-methylidene-δ-valerolactones with aziridines

Article abstract of DOI:10.1021/jo2006158

A palladium-catalyzed formal [6 + 3] cyclization of γ-methylidene- δ-valerolactones with aziridines has been developed to produce 1,4-oxazonan-9-ones, a class of nine-membered azlactones that are not easily accessible by existing methods. The products thus obtained can also be further functionalized with ease.