Resolution of Diels-Alder Adducts Using Chiral Carbodiimide

Article abstract of DOI:10.1246/cl.1990.1009

The relation between the separability and the stereochemistry of the acylurea derivatives prepared from chiral mono-, bi- and tricyclic acids and N,N'-bis((S)-1-phenylethyl)carbodiimide were investigated.Conventionally separated diasteromers by silica gel column chromatography were converted to optically pure methyl esters of the corresponding acids upon methanolysis.