Toward chemical ribonucleases. 2. Synthesis and characterization of nucleoside-bipyridine conjugates. Hydrolytic cleavage of RNA by their copper(II) complexes

Article abstract of DOI:10.1021/ja00001a041

As part of our program to develop chemical ribonucleases that cleave RNA by phosphodiester hydrolysis, a systematic study of covalently linked nucleoside-2,2′-bipyridine (bpy) conjugates is described. 2′-Deoxythymidine was attached at both its 3′- and 5′-