Synthesis and Biological Activity of Methotrexate Analogues with Two Acid Groups and a Hydrophobic Aromatic Ring in the Side Chain

DOI: 10.1021/jm00106a016

Source and publish data:

Journal of Medicinal Chemistry p. 574 - 579 (1991)

Update date:2022-09-26

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Authors:

Rosowsky, Andre

Bader, Henry

Freisheim, James H.

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Article abstract of DOI:10.1021/jm00106a016

The heretofore unknown γ-(m-carboxylanilide) and γ-(m-boronoanilide) derivatives of methotrexate (MTX) and γ-(m-carboxyanilide) derivatives of aminopterin (AMT) were prepared and tested as inhibitors of dihydrofolate reductase (DHFR) and as inhibitors of

Full text of DOI:10.1021/jm00106a016

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