A large-scale synthesis of potent glucokinase activator MK-0941 via selective o -arylation and o -alkylation

DOI: 10.1021/op200068c

Source and publish data:

Organic Process Research and Development p. 824 - 830 (2011)

Update date:2022-08-03

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Authors:

Yoshikawa, Naoki

Xu, Feng

Arredondo, Juan D.

Itoh, Takahiro

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Article abstract of DOI:10.1021/op200068c

An efficient, practical preparation of MK-0941, a potent glucokinase activator, is described. Keys to the success of the synthesis are a highly selective mono-O-arylation of methyl 3,5-dihydroxybenzoate with 2-ethanesulfonyl-5-chloropyridine and the choic

Full text of DOI:10.1021/op200068c

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