An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synthesis

Article abstract of DOI:10.1016/S0040-4039(98)01668-2

The synthesis of an o-nitrobenzyl photolabile linker (1) from o- nitrobenzaldehyde is described, and the efficiency of its light-mediated (365 nm) cleavage is found to be comparable to related, previously developed systems. In contrast, 1 is shown to be stable to acid, base, and Lewis acid/amine combinations while the previously developed linker 2 is shown to degrade under the latter two conditions.