The first total synthesis of (±)-cyclophostin and (±)-cyclipostin P: Inhibitors of the serine hydrolases acetyl cholinesterase and hormone sensitive lipase

Article abstract of DOI:10.1021/ol200991x

Cyclophostin, a structurally unique and potent naturally occurring acetyl cholinesterase (AChE) inhibitor, and its unnatural diastereomer were prepared in 6 steps and 15% overall yield from hydroxymethyl butyrolactone. The unnatural diastereomer of cyclop