Novel 5-HT3 antagonists. Indole oxadiazoles.

DOI: 10.1021/jm00105a021

Source and publish data:

Journal of medicinal chemistry p. 140 - 151 (1991)

Update date:2022-09-26

Topics:

Authors:

Swain Swain

Baker Baker

Kneen Kneen

Moseley Moseley

Saunders

Seward Seward

Stevenson

Beer Beer

Stanton Stanton

Watling Watling

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a021

The synthesis and biochemical evaluation of a series of indole oxadiazole 5-HT3 antagonists are described. The key pharmacophoric elements have been defined as a basic nitrogen, a linking group capable of H-bonding interactions, and an aromatic moiety. Th

Full text of DOI:10.1021/jm00105a021

Products guided by the article

Product name:Phenol, 3-[5-(1-azabicyclo[2.2.2]oct-3-yl)-1,2,4-oxadiazol-3-yl]-

Cas No:131013-00-8

R&D Labs maybe for 131013-00-8

Jinan Hongfangde Pharmatech Co.,Ltd

Contact:86-531-88870908

Address:F Bldg. West Unit North Area of Univ. Tech. Garden Xinyu Rd. Jinan New & High Tech Industry Development Zone Shandong, China
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.

Contact:+86-25-83767696

Address:14-7 Zhongshan Lu Guluo District, Nanjing
ZHEJIANG JIANYE CHEMICAL CO.,LTD.

Contact:86-571-64149273,64149234

Address:No. 48, Fuxi Road, Meicheng Town
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Chengdu Gelipu Biotechnology Co., Ltd.

website:http://www.glp-china.com

Contact:86-28-82610909

Address:chegndu

Relevant to this article

Pentacoordinated silicon compounds. Intramolecular ring closure, site preferences of substituents and the stability of the resulting chelates

Doi:10.1016/0022-328X(90)85258-Z
(1990)
Cyclopropylhydroxycarbene

Doi:10.1021/ja204507j
(2011)
Diversity-oriented synthesis of 1,3-benzodiazepines

Doi:10.1016/j.tet.2017.09.034
(2017)
Synthesis of Substituted Cyclic 1,3-Dienes via Selective 1,4-Elimination of Benzenesulfinic Acid from Allylic Phenyl Sulfones

Doi:10.1021/jo00002a061
(1991)
Ruthenium arene derivatives of chiral ferrocene-based P,N or P,O ligands. Transformation of chloro-alcohol into hydrido-carbonyl complexes

Doi:10.1021/om1008132
(2011)
Electronic perturbations of iron dipyrrinato complexes via ligand β-halogenation and meso-fluoroarylation

Doi:10.1021/ic2009539
(2011)

Article Doi