Synthesis, Peroxidating Ability, and Antineoplastic Evaluation of 1--4-hydroxy-10-imino-9-anthracenones

DOI: 10.1021/jm00106a009

Source and publish data:

Journal of Medicinal Chemistry p. 541 - 546 (1991)

Update date:2022-08-03

Topics:

Authors:

Dzieduszycka, Maria

Martelli, Sante

Tarasiuk, Jolanta

Paradziej-Lukowicz, Jolanta

Borowski, Edward

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Article abstract of DOI:10.1021/jm00106a009

A novel group of cytotoxic anthraquinone derivatives, 1-<(aminoalkyl)amino>-4-hydroxy-10-imino-9-anthracenones, has been synthesized.It has been shown that imino analogues of the anthracenediones exhibit diminished ability to generate oxygen radicals.The cytotoxic activity of iminoanthracenones obtained was lower than that of the related quinone carbonyl analogues.One of the obtained imino compounds showed a moderate antileukemic activity in vivo.

Full text of DOI:10.1021/jm00106a009

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Product name:1-<(2-aminoethyl)amino>-4-hydroxy-9,10-anthracenedione hydrochloride

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