Structure-guided redesign of d-fructose-6-phosphate aldolase from E. coli: Remarkable activity and selectivity towards acceptor substrates by two-point mutation

DOI: 10.1039/c1cc11069a

Source and publish data:

Chemical Communications p. 5762 - 5764 (2011)

Update date:2022-08-03

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Authors:

Gutierrez, Mariana

Parella, Teodor

Joglar, Jesus

Bujons, Jordi

Clapes, Pere

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Article abstract of DOI:10.1039/c1cc11069a

Structure-guided re-design of the acceptor binding site of d-fructose-6-phosphate aldolase from E. coli leads to the construction of FSA A129S/A165G double mutant with an activity between 5- to >900-fold higher than that of wild-type towards N-Cbz-aminoal

Full text of DOI:10.1039/c1cc11069a

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