Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys

Article abstract of DOI:10.1021/jm00106a026

We previously reported that Boc-Pro-Phe-N-MeHis-Leuψ[CHOHCH₂]-Ile-Amp (1) is a potent and specific inhibitor of human renin in vitro. It was shown to resist degradation by selected proteases and a rat liver homogenate. It was shown to inhibit p