Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase

DOI: 10.1021/jm00105a035

Source and publish data:

Journal of Medicinal Chemistry p. 222 - 227 (1991)

Update date:2022-09-26

Topics:

Authors:

Abraham Abraham

McGuire McGuire

Galivan Galivan

Nimec Nimec

Kisliuk Kisliuk

Gaumont Gaumont

Nair Nair

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a035

Five analogues of methotrextate (MTX), 10-deazaaminopterin (10-DAM), and 10-ethyl-10-deazaaminopterin (10-EDAM) in which the glutamate moiety was replaced by either a γ-methyleneglutamate or β-hydroxyglutamate were synthesized and evaluated for their anti

Full text of DOI:10.1021/jm00105a035

Products guided by the article

Product name:2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-4-methylene-pentanedioic acid

Cas No:131216-22-3

R&D Labs maybe for 131216-22-3

PharmOrgsyn

Contact:+86-21-38228826

Address:Room 505 Building 2, No 3377 Kangxin Highway, Shanghai, Republic China
Henan zhongda Biological Engineering Co., Ltd

Contact:86-28-18109029985

Address:shenzhou road,xuedian industrial estate,zhengzhou city,henan province CHN
Chengdu Push Bio-technology Co., Ltd

Contact:--

Address:No.8 Wuke West Second Road, Wuhou
Hangzhou Showland Technology Co., Ltd.

Contact:86-571-88920516

Address:ROOM2118,NO.553,WENSAN ROAD,HANGZHOU,CHINA
Taizhou YOJOY Chemical Co., Ltd.

Contact:13857143241

Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China

Relevant to this article

Mild air-oxidation of 1,3-dicarbonyl compounds with cesium salts: Novel α-hydroxylation accompanied by partial hydrolysis of malonate derivatives

Doi:10.1016/S0040-4039(99)01618-4
(1999)
Stereochemical analysis of deuterated alkyl chains by MS/MS

Doi:10.1021/jo9912247
(2000)
Sequential [3+2] cycloaddition/rearrangement reaction of imidazolone nitrones and allenoates for the efficient synthesis of functionalized imidazolidinone

Doi:10.1016/j.tetlet.2011.11.049
(2012)
C-O versus C-C bond cleavage: Selectivity control in Lewis acid catalyzed chemodivergent cycloadditions of aryl oxiranyldicarboxylates with aldehydes, and theoretical rationalizations of reaction pathways

Doi:10.1002/chem.201201453
(2012)
Halo(alkoxo) and Monocyclopentadienyl(halo)alkoxo Derivatives of Titanium, Zirconium and Hafnium

Doi:10.1016/0022-328X(86)80453-3
(1986)
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid

Doi:10.1016/j.bmcl.2011.11.123
(2012)

Article Doi