Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase

DOI: 10.1021/jm00105a035

Source and publish data:

Journal of Medicinal Chemistry p. 222 - 227 (1991)

Update date:2022-09-26

Topics:

Authors:

Abraham Abraham

McGuire McGuire

Galivan Galivan

Nimec Nimec

Kisliuk Kisliuk

Gaumont Gaumont

Nair Nair

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Article abstract of DOI:10.1021/jm00105a035

Five analogues of methotrextate (MTX), 10-deazaaminopterin (10-DAM), and 10-ethyl-10-deazaaminopterin (10-EDAM) in which the glutamate moiety was replaced by either a γ-methyleneglutamate or β-hydroxyglutamate were synthesized and evaluated for their anti

Full text of DOI:10.1021/jm00105a035

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